DISEASE SCANNER
Global Incurable Diseases Tracker
Wilms Tumor (Nephroblastoma)
The most common renal malignancy in children, typically affecting ages 3-4 years. Often associated with WT1 or WT2 gene mutations. Can be part of syndromes (WAGR, Denys-Drash, Beckwith-Wiedemann). Excellent prognosis with treatment.
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Symptoms
Treatment Options
Risk Factors
Diagnostic Methods
- 1Biopsy
- 2Imaging (CT, MRI, PET)
- 3Tumor markers
- 4Genetic testing
- 5Endoscopy
- 6Blood tests
- 7Screening programs
Prognosis
Excellent prognosis overall. Overall 5-year survival 90%. Favorable histology: 95% survival. Unfavorable (anaplastic) histology: 70% survival. Stage I-II: 95-98% survival. Stage III: 85-90% survival. Stage IV: 75% survival. Stage V (bilateral): 80% survival. Nephron-sparing surgery when possible. Chemotherapy highly effective. Radiation for advanced stages. Long-term survivors monitored for treatment effects (heart, kidney). Fertility usually preserved. Cure rates have improved dramatically over past decades.
Prevention
- Smoking cessation
- Sun protection
- Healthy diet
- Regular exercise
- Vaccination (HPV, HBV)
- Screening programs
- Limit alcohol
- Maintain healthy weight
Research Status
Nephrectomy and chemotherapy (vincristine, actinomycin, doxorubicin). Radiation for advanced stages. Bilateral kidney-sparing surgery. Survival >90% overall. Risk-stratified therapy based on histology and stage.
Affected Countries
Sources
- https://www.cancer.gov
- https://www.who.int/cancer
- https://www.cancer.org
Medical Disclaimer
This information is for educational purposes only. Always consult healthcare professionals for medical advice, diagnosis, and treatment.