DISEASE SCANNER

Global Incurable Diseases Tracker

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Gynecologic Condition

Vulvar Intraepithelial Neoplasia (VIN)

MODERATE

Abnormal cell growth on the vulva, considered a precancerous condition. Associated with HPV infection and can progress to vulvar cancer if untreated.

Global Affected

180.0K

Countries

15

Symptoms

Chronic vulvar itching
Burning sensation
Vulvar pain or soreness
White or red patches on vulva
Raised lesions or warts
Pain during intercourse

Treatment Options

Topical imiquimod cream
Topical 5-fluorouracil (5-FU)
Laser ablation
Surgical excision
Skinning vulvectomy (extensive cases)
Photodynamic therapy

Risk Factors

1HPV infection (types 16, 18)
2Smoking
3Immunosuppression
4Lichen sclerosus
5Age 40-60 years
6Multiple sexual partners

Diagnostic Methods

  • 1Vulvar biopsy
  • 2Colposcopy of vulva
  • 3Acetic acid application
  • 4HPV testing
  • 5Punch biopsy

Prognosis

Excellent with treatment. Progression to invasive vulvar cancer occurs in 5-10% of untreated cases. Recurrence rate of 10-20% after treatment. Regular surveillance essential. HPV-related VIN has better prognosis than differentiated type. 95% cure rate with complete excision. Lifelong monitoring recommended.

Prevention

  • HPV vaccination
  • Smoking cessation
  • Regular gynecologic examinations
  • Treatment of lichen sclerosus
  • Safe sex practices

Research Status

Surgical excision, laser therapy, or topical treatments (imiquimod, 5-FU). Regular vulvar examinations. HPV vaccination for prevention. Wide local excision for high-grade lesions.

Affected Countries

United StatesUnited KingdomCanadaAustraliaGermanyFranceItalySpainJapanBrazilMexicoIndiaSouth AfricaNigeriaKenya

Sources

  • https://www.cancer.gov/types/vulvar/patient/vulvar-treatment-pdq
  • https://www.acog.org/clinical/clinical-guidance/practice-bulletin/articles/2011/07/diagnosis-and-management-of-vulvar-skin-disorders
  • https://www.ncbi.nlm.nih.gov/books/NBK567760

Medical Disclaimer

This information is for educational purposes only. Always consult healthcare professionals for medical advice, diagnosis, and treatment.