The most common inherited bleeding disorder, caused by deficiency or dysfunction of von Willebrand factor (vWF), essential for platelet adhesion and as carrier for factor VIII. Three main types with varying severity.

• 1Genetic testing
• 2Clinical evaluation
• 3Family history assessment
• 4Specialized laboratory tests
• 5Imaging studies
• 6Biopsy (if applicable)

Excellent with proper management. Type 1 (mild): normal life expectancy, treatment only for surgery or significant bleeding. Type 2: moderate severity, treatment during bleeding episodes and procedures. Type 3 (severe): regular prophylactic treatment may be needed, life expectancy near normal with care. Desmopressin effective for Types 1 and some 2. VWF concentrate available for all types. Pregnancy usually well-tolerated. Dental and surgical procedures manageable with planning. Quality of life excellent with education and preparation.

• Genetic counseling
• Carrier screening
• Prenatal diagnosis
• Preimplantation genetic diagnosis
• Family planning