DISEASE SCANNER

Global Incurable Diseases Tracker

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Chronic Condition

Uterine Fibroids (Leiomyomas)

MODERATE

Benign smooth muscle tumors of the uterus, extremely common in women of reproductive age. Can cause heavy bleeding, pain, and reproductive issues. Vary greatly in size from microscopic to massive tumors distorting the uterus.

Global Affected

170.0M

Countries

15

Symptoms

Heavy menstrual bleeding
Prolonged periods
Pelvic pressure/pain
Frequent urination
Constipation
Back pain
Pain during intercourse
Infertility/recurrent miscarriage

Treatment Options

Watchful waiting
GnRH agonists
Ulipristal acetate
Myomectomy
Hysterectomy
Uterine artery embolization
MRI-guided focused ultrasound
Radiofrequency ablation

Risk Factors

1African ancestry (2-3x risk)
2Family history
3Early menarche
4Obesity
5Nulliparity
6Vitamin D deficiency
7Alcohol consumption

Diagnostic Methods

  • 1Pelvic examination
  • 2Transvaginal ultrasound
  • 3Saline infusion sonography
  • 4MRI (for surgical planning)
  • 5Hysteroscopy

Prognosis

Benign tumors. Shrink after menopause. Recurrence after myomectomy is 15-30%. Hysterectomy is curative. Most women have good outcomes with appropriate treatment.

Prevention

  • No proven prevention
  • Maintaining healthy weight
  • Adequate vitamin D
  • Regular exercise

Research Status

GnRH agonists (leuprolide) temporarily shrink fibroids. Uterine artery embolization (UAE), myomectomy, or hysterectomy surgical options. Elagolix combinations approved. Selective progesterone receptor modulators (ulipristal) available in some countries.

Affected Countries

United StatesUnited KingdomCanadaAustraliaGermanyFranceItalySpainJapanChinaIndiaBrazilMexicoNigeriaSouth Africa

Sources

  • https://medlineplus.gov
  • https://www.mayoclinic.org
  • https://www.hematology.org/education/patients
  • https://www.ncbi.nlm.nih.gov/books
  • https://rarediseases.org/rare-diseases

Medical Disclaimer

This information is for educational purposes only. Always consult healthcare professionals for medical advice, diagnosis, and treatment.