DISEASE SCANNER

Global Incurable Diseases Tracker

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Autoimmune Disease

Ulcerative Colitis

MODERATE

A chronic inflammatory bowel disease causing inflammation and ulcers in the innermost lining of the colon and rectum. Limited to continuous mucosal inflammation of the colon. Risk of colorectal cancer increased after 8-10 years of disease.

Global Affected

5.0M

Countries

15

Symptoms

Bloody diarrhea
Abdominal pain and cramping
Rectal urgency and tenesmus
Fatigue
Weight loss
Fever

Treatment Options

Corticosteroids
Immunosuppressants
Biologic agents
DMARDs
Plasmapheresis
IVIG
Physical therapy
Symptom management

Risk Factors

1Female gender
2Family history
3Genetic predisposition
4Environmental triggers
5Infections
6Hormonal factors
7Smoking

Diagnostic Methods

  • 1Autoantibody testing
  • 2Inflammatory markers
  • 3Imaging
  • 4Biopsy
  • 5Clinical criteria
  • 6Exclusion of other causes

Prognosis

Variable; many autoimmune diseases are chronic with relapsing-remitting courses. Early treatment and modern biologics have significantly improved outcomes.

Prevention

  • No specific prevention
  • Smoking cessation
  • Avoidance of triggers
  • Early diagnosis and treatment
  • Regular monitoring

Research Status

JAK inhibitors (upadacitinib, tofacitinib), S1P modulators (ozanimod, etrasimod) approved. Anti-integrin (vedolizumab) and IL-12/23 (ustekinumab) effective. Colectomy curative for refractory disease.

Affected Countries

AustraliaCanadaGermanyEgyptSpainFinlandFranceUnited KingdomItalyJapanNorwayPolandSwedenUnited StatesVietnam

Sources

  • https://www.ncbi.nlm.nih.gov/books/NBK519046
  • https://www.ncbi.nlm.nih.gov/books
  • https://www.mayoclinic.org/diseases-conditions
  • https://rarediseases.org/rare-diseases

Medical Disclaimer

This information is for educational purposes only. Always consult healthcare professionals for medical advice, diagnosis, and treatment.