DISEASE SCANNER

Global Incurable Diseases Tracker

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Cancer

Gastric (Stomach) Cancer

HIGH SEVERITY

Adenocarcinoma of the stomach, often associated with H. pylori infection, smoking, diet (salted/preserved foods), and genetic factors. Incidence declining in West but remains high in East Asia. Lauren classification: intestinal and diffuse types.

Global Affected

1.1M

Countries

15

Symptoms

Dyspepsia (indigestion)
Early satiety
Abdominal pain
Nausea
Weight loss
GI bleeding
Anemia

Treatment Options

Surgery
Chemotherapy
Radiation therapy
Immunotherapy
Targeted therapy
Hormone therapy
Stem cell transplant
Palliative care

Risk Factors

1Age
2Family history
3Genetic mutations
4Smoking
5Alcohol consumption
6Obesity
7Physical inactivity
8Environmental exposures
9Infections (HPV, HBV, HCV, H. pylori)

Diagnostic Methods

  • 1Biopsy
  • 2Imaging (CT, MRI, PET)
  • 3Tumor markers
  • 4Genetic testing
  • 5Endoscopy
  • 6Blood tests
  • 7Screening programs

Prognosis

Improved with early detection. Stage I: 5-year survival 70-90%. Stage II: 5-year survival 50-60%. Stage III: 5-year survival 20-40%. Stage IV (metastatic): 5-year survival 5-10%. Overall 5-year survival approximately 32%. Curative potential with complete surgical resection. Chemotherapy and radiation improve outcomes. HER2-positive tumors respond to trastuzumab. MSI-high tumors respond to immunotherapy. Quality of life maintained with palliative care in advanced disease.

Prevention

  • Smoking cessation
  • Sun protection
  • Healthy diet
  • Regular exercise
  • Vaccination (HPV, HBV)
  • Screening programs
  • Limit alcohol
  • Maintain healthy weight

Research Status

HER2-targeted therapy (trastuzumab) for HER2+ disease. CLDN18.2-targeted therapy (zolbetuximab) approved. Immunotherapy (nivolumab, pembrolizumab) in combination. MSI-H tumors respond well to immunotherapy.

Affected Countries

BrazilCanadaChinaEgyptUnited KingdomIndonesiaIndiaItalyJapanSouth KoreaMexicoNigeriaTurkeyUnited StatesVietnam

Sources

  • https://www.cancer.gov
  • https://www.who.int/cancer
  • https://www.cancer.org

Medical Disclaimer

This information is for educational purposes only. Always consult healthcare professionals for medical advice, diagnosis, and treatment.