DISEASE SCANNER

Global Incurable Diseases Tracker

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Cancer

Squamous Cell Carcinoma

MODERATE

The second most common type of skin cancer, arising from squamous cells in the epidermis. More aggressive than BCC with metastatic potential. UV exposure main risk factor.

Global Affected

1.5M

Countries

22

Symptoms

Firm, red nodule
Flat lesion with scaly crust
New sore or raised area
Rough, scaly patch
Wart-like growth
Open sore that bleeds
Persistent scaly red patch

Treatment Options

Surgical excision
Mohs micrographic surgery
Radiation therapy
Cryotherapy
Curettage and electrodesiccation
Topical chemotherapy
Photodynamic therapy
Immunotherapy
Targeted therapy

Risk Factors

1UV exposure
2Fair skin
3Age
4History of precancerous lesions (actinic keratosis)
5Previous SCC
6Immunosuppression
7Chronic skin ulcers
8Exposure to arsenic or coal tar
9HPV infection
10Radiation therapy

Diagnostic Methods

  • 1Physical examination
  • 2Dermoscopy
  • 3Skin biopsy
  • 4Imaging (if advanced)
  • 5Sentinel lymph node biopsy (high-risk)

Prognosis

Good when detected early; 95%+ cure rate. Metastasis rate 2-5% for high-risk lesions. Immunosuppressed patients have higher risk. Regular follow-up important for early detection of recurrences and new lesions.

Prevention

  • Sun protection
  • Avoid tanning beds
  • Regular skin exams
  • Treat actinic keratoses
  • Don't smoke

Research Status

Surgery remains mainstay. Mohs for high-risk lesions. Sentinel lymph node biopsy for advanced cases. Immunotherapy (cemiplimab, pembrolizumab) for metastatic. EGFR inhibitors for some cases.

Affected Countries

United StatesUnited KingdomCanadaAustraliaNew ZealandGermanyFranceItalySpainJapanBrazilMexicoAustraliaNew ZealandSwedenNorwayFinlandDenmarkNetherlandsBelgiumSwitzerlandAustria

Sources

  • https://www.aad.org/public/diseases/skin-cancer/types/common/scc
  • https://www.cancer.org/cancer/basal-and-squamous-cell-skin-cancer.html
  • https://www.skincancer.org/skin-cancer-information/squamous-cell-carcinoma
  • https://www.cancer.gov/

Medical Disclaimer

This information is for educational purposes only. Always consult healthcare professionals for medical advice, diagnosis, and treatment.