DISEASE SCANNER

Global Incurable Diseases Tracker

Back to Globe
Hematologic Disorder

Sickle Cell Trait

LOW SEVERITY

A genetic condition where a person inherits one sickle cell gene and one normal hemoglobin gene. Usually asymptomatic but can cause complications under extreme conditions. Different from sickle cell disease.

Global Affected

300.0M

Countries

20

Symptoms

Usually asymptomatic
Rarely: blood in urine
Rarely: splenic infarction at high altitude
Rarely: exertional rhabdomyolysis
Rarely: pregnancy complications

Treatment Options

Usually none needed
Genetic counseling
Hydration during extreme exercise
Avoidance of severe hypoxia
Monitoring during pregnancy

Risk Factors

1Inherited (one parent with sickle cell gene)
2African, Mediterranean, Middle Eastern, South Asian, Caribbean, Central/South American ancestry

Diagnostic Methods

  • 1Newborn screening
  • 2Hemoglobin electrophoresis
  • 3Sickle cell solubility test
  • 4Genetic testing
  • 5Complete blood count

Prognosis

Excellent. Normal life expectancy. Usually no symptoms. Rare complications. Malaria resistance benefit. Important to know status for family planning.

Prevention

  • Genetic counseling
  • Newborn screening
  • Prenatal testing
  • Carrier screening
  • Informed family planning

Research Status

Most people live normal lives. Malaria resistance advantage. Potential renal complications. Exercise-related deaths rare but documented. Genetic counseling important for family planning. No treatment usually needed.

Affected Countries

United StatesUnited KingdomCanadaAustraliaNigeriaSouth AfricaGhanaMaliBFDR CongoTanzaniaIndiaBrazilMexicoJMHaitiGreeceItalySpainTurkey

Sources

  • https://www.cdc.gov/ncbddd/sicklecell/traits.html
  • https://www.mayoclinic.org/diseases-conditions/sickle-cell-anemia
  • https://www.hematology.org/education/patients
  • https://www.ncbi.nlm.nih.gov/books
  • https://rarediseases.org/rare-diseases

Medical Disclaimer

This information is for educational purposes only. Always consult healthcare professionals for medical advice, diagnosis, and treatment.