DISEASE SCANNER
Global Incurable Diseases Tracker
Polymyositis
A rare inflammatory muscle disease causing progressive muscle weakness, particularly in the proximal muscles (shoulders, hips, thighs). Belongs to idiopathic inflammatory myopathies. Affects adults primarily, rare in children. Associated with interstitial lung disease in some cases.
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Symptoms
Treatment Options
Risk Factors
Diagnostic Methods
- 1Muscle enzymes (CK, aldolase)
- 2Antinuclear antibody (ANA)
- 3Myositis-specific antibodies
- 4Muscle biopsy
- 5MRI of muscles
- 6EMG (electromyography)
- 7Chest CT (lung involvement)
- 8Pulmonary function tests
Prognosis
Variable but generally good with treatment. Most improve significantly with immunosuppressive therapy. Some have residual weakness. Relapses occur. Mortality 10-20% (often from lung disease or complications). Physical therapy crucial for recovery. Lifelong treatment often needed. Quality of life improves with treatment.
Prevention
- No known prevention
- Early diagnosis and treatment
- Physical therapy to maintain function
- Fall prevention strategies
- Pneumonia vaccination
- Regular monitoring
- Prompt treatment of infections
Research Status
Corticosteroids first-line. Immunosuppressants (methotrexate, azathioprine, mycophenolate). IVIG for refractory cases. Rituximab increasingly used. Physical therapy essential. Treatment of interstitial lung disease if present. Early aggressive treatment recommended. Most improve with therapy.
Affected Countries
Sources
- https://www.mayoclinic.org/diseases-conditions/polymyositis
- https://www.ncbi.nlm.nih.gov/books
- https://www.mayoclinic.org/diseases-conditions
- https://rarediseases.org/rare-diseases
Medical Disclaimer
This information is for educational purposes only. Always consult healthcare professionals for medical advice, diagnosis, and treatment.