DISEASE SCANNER

Global Incurable Diseases Tracker

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Urologic Condition

Peyronie's Disease

MODERATE

A connective tissue disorder characterized by the development of fibrous scar tissue (plaque) inside the penis, causing curved, painful erections. Affects 3-9% of men, most commonly between ages 45-60. Can significantly impact sexual function and psychological well-being.

Global Affected

10.0M

Countries

111

Symptoms

Penile curvature (upward, downward, or sideways)
Scar tissue (plaque) felt under skin
Pain during erections
Erectile dysfunction
Shortening of penis
Penile narrowing or hourglass deformity
Difficulty with penetration
Anxiety and depression

Treatment Options

Collagenase injections (Xiaflex)
Penile traction therapy
Intralesional verapamil
Intralesional interferon
Nesbit plication surgery
Grafting surgery
Penile prosthesis implant
Oral pentoxifylline
Vitamin E (limited evidence)

Risk Factors

1Age 45-60
2Dupuytren's contracture
3Plantar fascial fibromatosis
4Diabetes
5Hypertension
6Smoking
7Excessive alcohol
8Penile trauma (sexual or sports)
9Prostate surgery
10Autoimmune disease

Diagnostic Methods

  • 1Physical examination (palpable plaque)
  • 2Photography of erect penis
  • 3Duplex Doppler ultrasound
  • 4Penile dynamic ultrasound
  • 5Assessment of curvature degree
  • 6Erectile function assessment

Prognosis

Variable; 13% improve spontaneously, 40% stabilize, 47% worsen without treatment. Early intervention during acute phase may prevent progression. Surgery successful in 80-90% of cases but carries risks. Curvature >30 degrees often requires intervention. Psychological support important.

Prevention

  • No proven prevention
  • Avoid penile trauma
  • Use protective equipment in sports
  • Gentle sexual techniques
  • Don't smoke
  • Manage cardiovascular risk factors

Research Status

Collagenase clostridium histolyticum (Xiaflex) FDA-approved for treatment. Penile traction therapy. Intralesional verapamil and interferon. Surgery (plication, grafting, prosthesis) for stable disease refractory to medical therapy. Emerging: shockwave therapy, PRP injections. Most cases stabilize spontaneously within 12-18 months.

Affected Countries

United StatesUnited KingdomCanadaAustraliaGermanyFranceItalySpainJapanChinaIndiaBrazilRussiaSwedenNetherlandsBelgiumSwitzerlandAustriaDenmarkNorwayFinlandPolandCzech RepublicHungaryRomaniaBulgariaCroatiaSloveniaSlovakiaLTLVEEIrelandPortugalGreeceCYMTLUIcelandNew ZealandSouth KoreaSingaporeTaiwanHong KongMalaysiaThailandVietnamIndonesiaPhilippinesSouth AfricaNigeriaEgyptTurkeyIranSaudi ArabiaUAEQatarKuwaitOmanJordanLebanonSyriaYemenIraqAfghanistanPakistanBangladeshLKNPMMKHLAMNKazakhstanUzbekistanTMKGTJAzerbaijanAMGEUkraineBelarusMDALBAMEMKSerbiaXKMexicoArgentinaChileColombiaPeruVenezuelaEcuadorUYPYBOCRPAGuatemalaHNSVNIBZJMHaitiDominican RepublicCuba

Sources

  • https://www.niddk.nih.gov/health-information/urologic-diseases/peyronies-disease
  • https://www.mayoclinic.org/diseases-conditions/peyronies-disease/symptoms-causes/syc-20353468
  • https://www.hematology.org/education/patients
  • https://www.ncbi.nlm.nih.gov/books
  • https://rarediseases.org/rare-diseases

Medical Disclaimer

This information is for educational purposes only. Always consult healthcare professionals for medical advice, diagnosis, and treatment.