DISEASE SCANNER
Global Incurable Diseases Tracker
Osteosarcoma
The most common primary malignant bone tumor in children and adolescents, typically occurring at metaphysis of long bones. Associated with rapid growth and TP53 mutations. Peak incidence during adolescent growth spurt.
80.0K
15
Symptoms
Treatment Options
Risk Factors
Diagnostic Methods
- 1Biopsy
- 2Imaging (CT, MRI, PET)
- 3Tumor markers
- 4Genetic testing
- 5Endoscopy
- 6Blood tests
- 7Screening programs
Prognosis
Localized disease with chemotherapy + limb-salvage surgery has 65-75% long-term survival. Axial skeleton tumors have poorer prognosis (40-50%) than extremity tumors. Metastatic disease at presentation has 20-30% survival. Elevated LDH and alkaline phosphatase predict worse outcomes. Good histologic response to chemotherapy (>90% necrosis) predicts better survival. Recurrent disease has 20-30% salvage rate with surgery ± chemotherapy. Limb-salvage successful in 85-90% of cases.
Prevention
- Smoking cessation
- Sun protection
- Healthy diet
- Regular exercise
- Vaccination (HPV, HBV)
- Screening programs
- Limit alcohol
- Maintain healthy weight
Research Status
Neoadjuvant chemotherapy, limb-salvage surgery, and adjuvant chemotherapy. MAP protocol (methotrexate, doxorubicin, cisplatin). Survival 60-70% for localized; 20-30% for metastatic. mifamurtide (immunotherapy) approved in Europe.
Affected Countries
Sources
- https://www.cancer.gov
- https://www.who.int/cancer
- https://www.cancer.org
Medical Disclaimer
This information is for educational purposes only. Always consult healthcare professionals for medical advice, diagnosis, and treatment.