DISEASE SCANNER
Global Incurable Diseases Tracker
Osteoporosis
A systemic skeletal disease characterized by low bone mass and microarchitectural deterioration of bone tissue, leading to increased bone fragility and fracture risk. Often called the 'silent disease' because bone loss occurs without symptoms until fracture occurs.
200.0M
111
Symptoms
Treatment Options
Risk Factors
Diagnostic Methods
- 1Dual-energy X-ray absorptiometry (DXA)
- 2FRAX risk assessment tool
- 3Quantitative CT
- 4Bone turnover markers
- 5Vertebral fracture assessment
- 6X-rays for suspected fractures
Prognosis
With treatment, fracture risk reduced 40-70%. Untreated: 50% of women and 25% of men will have osteoporotic fracture after age 50.
Prevention
- Adequate calcium intake (1000-1200mg/day)
- Vitamin D supplementation
- Weight-bearing exercise
- Smoking cessation
- Limit alcohol
- Fall prevention strategies
Research Status
Denosumab and bisphosphonates remain mainstays. Romosozumab (sclerostin inhibitor) showing superior fracture reduction. Anabolic agents (teriparatide, abaloparatide) for severe osteoporosis. Gene therapy research exploring Wnt pathway modulation.
Affected Countries
Sources
- https://www.endocrine.org
- https://www.cdc.gov/
- https://www.hematology.org/education/patients
- https://www.ncbi.nlm.nih.gov/books
- https://rarediseases.org/rare-diseases
Medical Disclaimer
This information is for educational purposes only. Always consult healthcare professionals for medical advice, diagnosis, and treatment.