DISEASE SCANNER

Global Incurable Diseases Tracker

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Orthopedic Condition

Osteopenia

LOW SEVERITY

A condition where bone mineral density is lower than normal but not low enough to be classified as osteoporosis. Considered a precursor to osteoporosis and increases fracture risk compared to normal bone density. Often asymptomatic until a fracture occurs.

Global Affected

200.0M

Countries

83

Symptoms

Usually asymptomatic
Back pain (if compression fracture)
Loss of height
Stooped posture
Bone fracture with minimal trauma

Treatment Options

Calcium supplementation (1000-1200mg/day)
Vitamin D supplementation (800-1000 IU/day)
Weight-bearing exercise
Resistance training
Smoking cessation
Limit alcohol
Fall prevention strategies
Bisphosphonates (if high fracture risk)
Hormone therapy (select postmenopausal women)

Risk Factors

1Age >50
2Female gender
3Family history
4Low body weight
5Calcium/vitamin D deficiency
6Sedentary lifestyle
7Smoking
8Excessive alcohol
9Certain medications (steroids, anticonvulsants)
10Early menopause
11Low estrogen/testosterone
12Thyroid disorders
13Celiac disease
14Rheumatoid arthritis

Diagnostic Methods

  • 1DEXA scan (T-score -1.0 to -2.5)
  • 2FRAX risk assessment
  • 3Blood tests (calcium, vitamin D, thyroid)
  • 4Vertebral fracture assessment
  • 5QCT (quantitative CT)

Prognosis

Not all with osteopenia progress to osteoporosis. Many maintain stable bone density with lifestyle changes. Fracture risk intermediate between normal and osteoporosis. Early intervention can prevent progression. Many never develop osteoporosis with proper management.

Prevention

  • Adequate calcium intake
  • Vitamin D supplementation
  • Regular weight-bearing exercise
  • Resistance training
  • Avoid smoking
  • Limit alcohol
  • Fall prevention
  • Regular bone density screening

Research Status

Lifestyle modifications first-line: calcium, vitamin D, weight-bearing exercise. Pharmacologic treatment generally not recommended unless high fracture risk. FRAX tool assesses 10-year fracture risk. Monitoring with repeat DEXA scans every 2-5 years. Focus on fall prevention.

Sources

  • https://www.mayoclinic.org/diseases-conditions/osteoporosis
  • https://www.hematology.org/education/patients
  • https://www.ncbi.nlm.nih.gov/books
  • https://rarediseases.org/rare-diseases

Medical Disclaimer

This information is for educational purposes only. Always consult healthcare professionals for medical advice, diagnosis, and treatment.