DISEASE SCANNER
Global Incurable Diseases Tracker
Maturity-Onset Diabetes of the Young (MODY)
A group of monogenic diabetes disorders characterized by early onset (usually <25 years), autosomal dominant inheritance, and beta-cell dysfunction. Multiple genetic subtypes with different clinical features and treatment responses.
500.0K
15
Symptoms
Treatment Options
Risk Factors
Diagnostic Methods
- 1Genetic testing
- 2Clinical evaluation
- 3Family history assessment
- 4Specialized laboratory tests
- 5Imaging studies
- 6Biopsy (if applicable)
Prognosis
Excellent prognosis with proper management. MODY2 (GCK mutations) requires only lifestyle management; microvascular complications rare. MODY3 (HNF1A mutations) is very sensitive to low-dose sulfonylureas; insulin rarely needed. Other forms may require insulin or other agents. Misdiagnosis as type 1 or type 2 leads to inappropriate treatment. Genetic diagnosis allows family screening and tailored therapy. Life expectancy normal with proper management.
Prevention
- Genetic counseling
- Carrier screening
- Prenatal diagnosis
- Preimplantation genetic diagnosis
- Family planning
Research Status
MODY2 (GCK) often needs no treatment. MODY3 (HNF1A) responds excellently to low-dose sulfonylureas. Genetic testing essential for correct diagnosis and treatment. Misdiagnosed as type 1 or 2 diabetes.
Affected Countries
Sources
- https://www.ncbi.nlm.nih.gov/books/NBK1116
- https://medlineplus.gov/genetics
- https://rarediseases.org
Medical Disclaimer
This information is for educational purposes only. Always consult healthcare professionals for medical advice, diagnosis, and treatment.