DISEASE SCANNER
Global Incurable Diseases Tracker
Major Depressive Disorder
A common but serious mood disorder causing persistent feelings of sadness and loss of interest. Affects approximately 280 million people worldwide, leading cause of disability globally. Can occur at any age.
280.0M
111
Symptoms
Treatment Options
Risk Factors
Diagnostic Methods
- 1Clinical interview (DSM-5 criteria)
- 2PHQ-9 screening tool
- 3HAM-D assessment
- 4Medical evaluation (rule out causes)
- 5Thyroid function tests
- 6Substance use screening
Prognosis
50% recover after first episode; 50% have recurrent episodes. With treatment, 60-80% achieve significant improvement. 15% attempt suicide. Early treatment improves long-term outcomes.
Prevention
- Stress management
- Social support
- Regular exercise
- Adequate sleep
- Limiting alcohol
- Early intervention after trauma
- Screening programs
Research Status
SSRIs and SNRIs remain first-line. Esketamine nasal spray for treatment-resistant depression. Psilocybin trials showing rapid antidepressant effects. TMS and ECT for resistant cases. Digital therapeutics (app-based CBT). Biomarker research for personalized treatment.
Affected Countries
Sources
- https://www.cdc.gov/
- https://www.hematology.org/education/patients
- https://www.ncbi.nlm.nih.gov/books
- https://rarediseases.org/rare-diseases
Medical Disclaimer
This information is for educational purposes only. Always consult healthcare professionals for medical advice, diagnosis, and treatment.