DISEASE SCANNER

Global Incurable Diseases Tracker

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Autoimmune Disease

Systemic Lupus Erythematosus (SLE)

MODERATE

A chronic autoimmune disease where the immune system attacks healthy tissues, potentially affecting any organ system. Characterized by autoantibodies including ANA and anti-dsDNA. Nine times more common in women, especially of childbearing age and certain ethnicities.

Global Affected

5.0M

Countries

15

Symptoms

Fatigue
Joint pain and swelling
Malar rash (butterfly rash)
Photosensitivity
Oral ulcers
Kidney disease (lupus nephritis)
Pleuritis/pericarditis

Treatment Options

Corticosteroids
Immunosuppressants
Biologic agents
DMARDs
Plasmapheresis
IVIG
Physical therapy
Symptom management

Risk Factors

1Female gender
2Family history
3Genetic predisposition
4Environmental triggers
5Infections
6Hormonal factors
7Smoking

Diagnostic Methods

  • 1Autoantibody testing
  • 2Inflammatory markers
  • 3Imaging
  • 4Biopsy
  • 5Clinical criteria
  • 6Exclusion of other causes

Prognosis

Variable; many autoimmune diseases are chronic with relapsing-remitting courses. Early treatment and modern biologics have significantly improved outcomes.

Prevention

  • No specific prevention
  • Smoking cessation
  • Avoidance of triggers
  • Early diagnosis and treatment
  • Regular monitoring

Research Status

Belimumab (B-cell inhibitor) and Anifrolumab (type I interferon blocker) FDA-approved. CAR-T therapy showing promising results in early trials. Hydroxychloroquine remains backbone of therapy.

Affected Countries

AustraliaBrazilCanadaChinaGermanySpainFranceUnited KingdomIndiaItalyJapanMTMexicoUkraineUnited States

Sources

  • https://www.ncbi.nlm.nih.gov/books/NBK519046
  • https://www.ncbi.nlm.nih.gov/books
  • https://www.mayoclinic.org/diseases-conditions
  • https://rarediseases.org/rare-diseases

Medical Disclaimer

This information is for educational purposes only. Always consult healthcare professionals for medical advice, diagnosis, and treatment.