DISEASE SCANNER

Global Incurable Diseases Tracker

Cancer

Laryngeal Cancer

HIGH SEVERITY

Cancer of the voice box (larynx), most commonly squamous cell carcinoma. Strongly associated with tobacco and alcohol use. Hoarseness is the most common early symptom. Can affect voice, swallowing, and breathing depending on location.

Global Affected

180.0K

Countries

Symptoms

Hoarseness (>3 weeks)

Sore throat

Difficulty swallowing

Ear pain

Lump in neck

Persistent cough

Bad breath

Shortness of breath

Coughing up blood

Treatment Options

Surgery (laser, partial/total laryngectomy)

Radiation therapy

Chemotherapy

Chemoradiation

Immunotherapy

Targeted therapy

Speech therapy

Neck dissection

Risk Factors

1Tobacco smoking

2Heavy alcohol use

3HPV infection

4Age >55

5Male gender

6Gastroesophageal reflux

7Occupational exposures

8Poor nutrition

9Weakened immune system

Diagnostic Methods

1Laryngoscopy
2Biopsy
3CT/MRI of neck
4PET scan (staging)
5Chest imaging
6HPV testing
7Barium swallow

Prognosis

5-year survival 60% overall. Early (localized): 80-90%. Regional spread: 50-60%. Distant metastasis: 30-40%. Glottic (vocal cord) has best prognosis. Supraglottic (above) has higher spread risk.

Prevention

Smoking cessation
Limit alcohol
HPV vaccination
Healthy diet
Avoid occupational exposures
Regular dental checkups
Prompt evaluation of hoarseness

Research Status

Treatment depends on stage and location. Early: radiation or laser surgery. Advanced: combined surgery, radiation, chemotherapy. Larynx preservation protocols when possible. Immunotherapy for recurrent/metastatic disease. HPV-related cases have better prognosis.

Sources

https://www.cancer.org/cancer/types/laryngeal-cancer.html
https://www.cancer.gov/types/head-and-neck/patient/laryngeal-treatment-pdq
https://www.mayoclinic.org/diseases-conditions/laryngeal-cancer

Medical Disclaimer

This information is for educational purposes only. Always consult healthcare professionals for medical advice, diagnosis, and treatment.