DISEASE SCANNER

Global Incurable Diseases Tracker

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Autoimmune Disease

IgA Nephropathy (Berger's Disease)

MODERATE

The most common form of glomerulonephritis worldwide, caused by deposition of IgA antibodies in the glomeruli. Often presents with hematuria following upper respiratory infections. Can progress to chronic kidney disease.

Global Affected

2.5M

Countries

15

Symptoms

Blood in urine (gross or microscopic)
Proteinuria
High blood pressure
Swelling (edema)
Flank pain
Fatigue
Foamy urine

Treatment Options

Corticosteroids
Immunosuppressants
Biologic agents
DMARDs
Plasmapheresis
IVIG
Physical therapy
Symptom management

Risk Factors

1Female gender
2Family history
3Genetic predisposition
4Environmental triggers
5Infections
6Hormonal factors
7Smoking

Diagnostic Methods

  • 1Autoantibody testing
  • 2Inflammatory markers
  • 3Imaging
  • 4Biopsy
  • 5Clinical criteria
  • 6Exclusion of other causes

Prognosis

Variable; many autoimmune diseases are chronic with relapsing-remitting courses. Early treatment and modern biologics have significantly improved outcomes.

Prevention

  • No specific prevention
  • Smoking cessation
  • Avoidance of triggers
  • Early diagnosis and treatment
  • Regular monitoring

Research Status

Nefecon (budesonide) FDA-approved 2023. SGLT2 inhibitors showing benefit. Fish oil and ACE inhibitors may help. Corticosteroids for high-risk patients. Kidney transplant for ESRD, with risk of recurrence.

Affected Countries

United StatesUnited KingdomCanadaAustraliaGermanyFranceItalySpainJapanChinaIndiaBrazilMexicoSouth KoreaSingapore

Sources

  • https://www.ncbi.nlm.nih.gov/books/NBK519046
  • https://www.ncbi.nlm.nih.gov/books
  • https://www.mayoclinic.org/diseases-conditions
  • https://rarediseases.org/rare-diseases

Medical Disclaimer

This information is for educational purposes only. Always consult healthcare professionals for medical advice, diagnosis, and treatment.