DISEASE SCANNER

Global Incurable Diseases Tracker

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Endocrine Disorder

Hypoparathyroidism

HIGH SEVERITY

Deficiency of parathyroid hormone causing hypocalcemia and hyperphosphatemia. Most commonly due to thyroid/parathyroid surgery; can be autoimmune, genetic (DiGeorge, activating CaSR mutations), or idiopathic.

Global Affected

200.0K

Countries

15

Symptoms

Hypocalcemia
Tetany
Muscle cramps
Seizures
Paresthesias
Fatigue
Cataracts
Basal ganglia calcification

Treatment Options

Hormone replacement
Hormone suppression
Medications
Surgery
Radiation therapy
Lifestyle modifications
Regular monitoring

Risk Factors

1Family history
2Autoimmune disease
3Age
4Obesity
5Genetic mutations
6Iodine deficiency/excess
7Medications
8Pituitary tumors

Diagnostic Methods

  • 1Hormone level testing
  • 2Imaging (CT, MRI, ultrasound)
  • 3Stimulation/suppression tests
  • 4Autoantibody testing
  • 5Genetic testing

Prognosis

Generally excellent with proper hormone replacement or suppression. Lifelong monitoring typically required. Complications preventable with good control.

Prevention

  • Screening for at-risk individuals
  • Iodine sufficiency
  • Avoidance of trigger medications
  • Genetic counseling
  • Lifestyle modifications

Research Status

Calcium and active vitamin D supplementation. Recombinant PTH (Natpara) approved but recalled 2019. Careful monitoring to avoid hypercalciuria and nephrocalcinosis. Lifelong management.

Affected Countries

United StatesUnited KingdomCanadaAustraliaGermanyFranceItalySpainJapanBrazilMexicoNigeriaSouth AfricaIndiaChina

Sources

  • https://www.endocrine.org
  • https://www.ncbi.nlm.nih.gov/books/NBK278949
  • https://www.hematology.org/education/patients
  • https://www.ncbi.nlm.nih.gov/books
  • https://rarediseases.org/rare-diseases

Medical Disclaimer

This information is for educational purposes only. Always consult healthcare professionals for medical advice, diagnosis, and treatment.