DISEASE SCANNER

Global Incurable Diseases Tracker

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Endocrine Disorder

Primary Hyperparathyroidism

MODERATE

Overproduction of parathyroid hormone (PTH) usually due to a parathyroid adenoma, causing hypercalcemia. Most common cause of hypercalcemia in outpatients. Often asymptomatic but can cause kidney stones, osteoporosis, and neuropsychiatric symptoms.

Global Affected

1.0M

Countries

15

Symptoms

Often asymptomatic
Kidney stones
Osteoporosis
Fatigue
Depression
Constipation
Polyuria
Bone pain

Treatment Options

Hormone replacement
Hormone suppression
Medications
Surgery
Radiation therapy
Lifestyle modifications
Regular monitoring

Risk Factors

1Family history
2Autoimmune disease
3Age
4Obesity
5Genetic mutations
6Iodine deficiency/excess
7Medications
8Pituitary tumors

Diagnostic Methods

  • 1Hormone level testing
  • 2Imaging (CT, MRI, ultrasound)
  • 3Stimulation/suppression tests
  • 4Autoantibody testing
  • 5Genetic testing

Prognosis

Generally excellent with proper hormone replacement or suppression. Lifelong monitoring typically required. Complications preventable with good control.

Prevention

  • Screening for at-risk individuals
  • Iodine sufficiency
  • Avoidance of trigger medications
  • Genetic counseling
  • Lifestyle modifications

Research Status

Parathyroidectomy for symptomatic or severe/asymptomatic. Cinacalcet for those not surgical candidates. Observation for mild asymptomatic. Bone density monitoring. Regular calcium and kidney monitoring.

Affected Countries

United StatesUnited KingdomCanadaAustraliaGermanyFranceItalySpainJapanBrazilMexicoNigeriaSouth AfricaIndiaChina

Sources

  • https://www.endocrine.org
  • https://www.ncbi.nlm.nih.gov/books/NBK278949
  • https://www.hematology.org/education/patients
  • https://www.ncbi.nlm.nih.gov/books
  • https://rarediseases.org/rare-diseases

Medical Disclaimer

This information is for educational purposes only. Always consult healthcare professionals for medical advice, diagnosis, and treatment.