DISEASE SCANNER

Global Incurable Diseases Tracker

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Hematologic Disorder

Hemolytic Uremic Syndrome (HUS)

HIGH SEVERITY

A serious condition affecting blood and kidneys, characterized by hemolytic anemia, thrombocytopenia, and acute kidney injury. Most commonly caused by Shiga toxin-producing E. coli (STEC) infection. Atypical HUS is complement-mediated.

Global Affected

50.0K

Countries

15

Symptoms

Bloody diarrhea
Abdominal pain
Vomiting
Pale skin
Fatigue
Bruising
Decreased urination
Swelling
Confusion

Treatment Options

Transfusions
Iron supplementation
Vitamin supplementation
Erythropoietin
Immunosuppressants
Chemotherapy
Stem cell transplant
Gene therapy

Risk Factors

1Genetic mutations
2Family history
3Autoimmune disease
4Nutritional deficiencies
5Chronic disease
6Medications
7Environmental exposures

Diagnostic Methods

  • 1Complete blood count
  • 2Peripheral smear
  • 3Bone marrow biopsy
  • 4Coagulation studies
  • 5Hemoglobin electrophoresis
  • 6Flow cytometry
  • 7Genetic testing

Prognosis

Typical HUS: excellent recovery in 85-95%. aHUS: requires eculizumab, 5-year survival 90%+. Kidney recovery variable. Recurrence risk in aHUS without prophylaxis.

Prevention

  • Genetic counseling
  • Nutritional adequacy
  • Avoidance of triggers
  • Vaccinations
  • Regular monitoring
  • Family screening

Research Status

Supportive care for STEC-HUS; antibiotics contraindicated. Eculizumab (complement inhibitor) for atypical HUS. Plasma exchange for severe cases. Dialysis if needed. Avoidance of STEC through food safety.

Sources

  • https://www.hematology.org
  • https://medlineplus.gov/blooddiseases.html
  • https://www.hematology.org/education/patients
  • https://www.ncbi.nlm.nih.gov/books
  • https://rarediseases.org/rare-diseases

Medical Disclaimer

This information is for educational purposes only. Always consult healthcare professionals for medical advice, diagnosis, and treatment.