DISEASE SCANNER

Global Incurable Diseases Tracker

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Metabolic Disorder

Gout

MODERATE

Form of inflammatory arthritis caused by monosodium urate crystal deposition. Sudden severe joint pain, often in big toe. Associated with metabolic syndrome.

Global Affected

42.0M

Countries

15

Symptoms

Severe joint pain
Redness and swelling
Warmth
Limited motion
Tophi
Kidney stones

Treatment Options

Allopurinol
Febuxostat
Colchicine
NSAIDs
Corticosteroids

Risk Factors

1Hyperuricemia
2Obesity
3Hypertension
4Alcohol
5Male gender

Diagnostic Methods

  • 1Serum uric acid
  • 2Joint aspiration
  • 3Clinical criteria

Prognosis

Excellent with proper management. Highly manageable with modern therapy.

Prevention

  • Weight control
  • Limit alcohol
  • Reduce purine intake
  • Stay hydrated

Research Status

Xanthine oxidase inhibitors first-line. IL-17 inhibitors for refractory cases. Treat-to-target strategy (urate <6 mg/dL).

Affected Countries

AustraliaBrazilCanadaChinaGermanySpainFranceUnited KingdomIndiaItalyJapanMexicoPortugalRussiaUnited States

Sources

  • https://www.cdc.gov/
  • https://www.ncbi.nlm.nih.gov/books
  • https://rarediseases.org/rare-diseases
  • https://www.newbornscreening.info

Medical Disclaimer

This information is for educational purposes only. Always consult healthcare professionals for medical advice, diagnosis, and treatment.