DISEASE SCANNER

Global Incurable Diseases Tracker

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Genetic Disorder

Gilbert Syndrome

LOW SEVERITY

A benign genetic condition causing mild unconjugated hyperbilirubinemia due to reduced UDP-glucuronosyltransferase activity. Affected individuals have intermittent mild jaundice, often triggered by fasting, illness, or stress. No treatment needed.

Global Affected

300.0M

Countries

15

Symptoms

Mild jaundice
Yellowing of eyes
Triggered by fasting
Triggered by illness/stress
Asymptomatic between episodes

Treatment Options

Genetic counseling
Supportive care
Symptom management
Enzyme replacement (if applicable)
Physical therapy
Regular monitoring
Multidisciplinary care

Risk Factors

1Family history
2Genetic mutations
3Consanguinity
4Advanced paternal age
5Ethnic predisposition

Diagnostic Methods

  • 1Genetic testing
  • 2Clinical evaluation
  • 3Family history assessment
  • 4Specialized laboratory tests
  • 5Imaging studies
  • 6Biopsy (if applicable)

Prognosis

Excellent. Benign condition with no health impact. Normal life expectancy. May reduce cardiovascular risk. No treatment required.

Prevention

  • Genetic counseling
  • Carrier screening
  • Prenatal diagnosis
  • Preimplantation genetic diagnosis
  • Family planning

Research Status

No treatment needed. Benign condition. Reassurance only. May have lower cardiovascular disease risk (antioxidant effect of bilirubin). Important to distinguish from more serious liver diseases.

Affected Countries

United StatesUnited KingdomCanadaAustraliaGermanyFranceItalySpainJapanBrazilMexicoNigeriaSouth AfricaIndiaChina

Sources

  • https://www.ncbi.nlm.nih.gov/books/NBK1116
  • https://medlineplus.gov/genetics
  • https://rarediseases.org

Medical Disclaimer

This information is for educational purposes only. Always consult healthcare professionals for medical advice, diagnosis, and treatment.