DISEASE SCANNER

Global Incurable Diseases Tracker

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Psychiatric Condition

Generalized Anxiety Disorder (GAD)

MODERATE

A chronic mental health condition characterized by persistent, excessive, and uncontrollable worry about everyday situations and events. Affects 3-6% of adults worldwide, with women affected twice as often as men. Causes significant impairment in social, occupational, and other important areas of functioning.

Global Affected

273.0M

Countries

20

Symptoms

Persistent excessive worry
Restlessness or feeling on edge
Fatigue
Difficulty concentrating
Irritability
Muscle tension
Sleep disturbances
Physical symptoms (headaches, GI issues)
Exaggerated startle response

Treatment Options

Cognitive-behavioral therapy (CBT)
SSRIs (sertraline, escitalopram)
SNRIs (venlafaxine, duloxetine)
Buspirone
Benzodiazepines (short-term)
Mindfulness-based therapy
Exercise and lifestyle modifications
Support groups

Risk Factors

1Family history of anxiety disorders
2Female gender
3Chronic medical illness
4History of trauma or abuse
5Perfectionist personality traits
6Substance use
7Chronic stress
8Other mental health disorders

Diagnostic Methods

  • 1Clinical interview per DSM-5 criteria
  • 2GAD-7 screening questionnaire
  • 3HAM-A (Hamilton Anxiety Rating Scale)
  • 4Medical evaluation to rule out physical causes
  • 5Thyroid function tests
  • 6Assessment of functional impairment

Prognosis

With appropriate treatment, 50-60% of patients achieve remission. CBT provides sustained benefits with 50-60% response rates. SSRIs effective in 50-70% of cases. Relapse common if treatment discontinued prematurely (30-50% within 6 months). Chronic course with waxing and waning symptoms in 40-50% of patients. Comorbid depression worsens prognosis. Early intervention improves long-term outcomes. Combination therapy (medication + CBT) most effective for severe cases.

Prevention

  • Stress management techniques
  • Regular exercise
  • Adequate sleep hygiene
  • Limiting caffeine and alcohol
  • Early intervention for anxiety symptoms
  • Building social support networks
  • Mindfulness and relaxation practices

Research Status

Cognitive-behavioral therapy (CBT) and SSRIs/SNRIs are first-line treatments with comparable efficacy. Mindfulness-based interventions show promise. Research on neurobiological mechanisms, genetic factors, and personalized treatment approaches including pharmacogenomics.

Sources

  • https://www.mayoclinic.org/diseases-conditions/generalized-anxiety-disorder
  • https://www.who.int/news-room/fact-sheets/detail/anxiety-disorders
  • https://www.hematology.org/education/patients
  • https://www.ncbi.nlm.nih.gov/books
  • https://rarediseases.org/rare-diseases

Medical Disclaimer

This information is for educational purposes only. Always consult healthcare professionals for medical advice, diagnosis, and treatment.