DISEASE SCANNER

Global Incurable Diseases Tracker

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Gastroenterologic Disease

Gallbladder Cancer

HIGH SEVERITY

A relatively rare but aggressive cancer that begins in the gallbladder. Often diagnosed at advanced stage due to lack of early symptoms. Associated with gallstones and chronic inflammation.

Global Affected

120.0K

Countries

19

Symptoms

Abdominal pain (upper right)
Bloating
Fever
Unintended weight loss
Nausea
Jaundice
Lumps in abdomen

Treatment Options

Surgical resection
Extended cholecystectomy
Liver resection
Chemotherapy
Radiation therapy
Palliative care
Biliary drainage
Clinical trials

Risk Factors

1Gallstones
2Porcelain gallbladder
3Gallbladder polyps >1cm
4Chronic gallbladder infection
5Primary sclerosing cholangitis
6Obesity
7Age (older adults)
8Female gender
9Ethnicity (Native American, Hispanic)

Diagnostic Methods

  • 1Ultrasound
  • 2CT scan
  • 3MRI/MRCP
  • 4ERCP
  • 5PET scan
  • 6Biopsy
  • 7Tumor markers (CEA, CA 19-9)
  • 8Liver function tests

Prognosis

Poor overall due to late diagnosis. 5-year survival <20%. Early-stage disease (incidentally found) has better prognosis. Recurrence common. Prognosis depends on stage at diagnosis and resectability.

Prevention

  • Maintain healthy weight
  • Treat gallstones (if symptomatic)
  • Remove gallbladder for large polyps
  • Manage primary sclerosing cholangitis
  • Regular monitoring of high-risk patients

Research Status

Surgery offers only curative option. Extended cholecystectomy for resectable disease. Adjuvant chemotherapy beneficial. Gemcitabine-cisplatin standard for advanced disease. Immunotherapy being studied. Screening high-risk populations (porcelain gallbladder, polyps >1cm).

Sources

  • https://www.cancer.org/cancer/gallbladder-cancer.html
  • https://www.mayoclinic.org/diseases-conditions/gallbladder-cancer
  • https://www.cancer.gov/types/gallbladder

Medical Disclaimer

This information is for educational purposes only. Always consult healthcare professionals for medical advice, diagnosis, and treatment.