DISEASE SCANNER

Global Incurable Diseases Tracker

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Gastroenterologic Disease

Eosinophilic Esophagitis (EoE)

MODERATE

A chronic immune/antigen-mediated disease characterized by eosinophil-predominant inflammation of the esophagus. Associated with food allergies and atopic conditions. Increasing in incidence.

Global Affected

1.5M

Countries

16

Symptoms

Difficulty swallowing
Food impaction
Chest pain
Heartburn
Abdominal pain
Vomiting
Failure to thrive (children)

Treatment Options

Six-food elimination diet
Topical corticosteroids
Proton pump inhibitors
Dupilumab
Elemental diet
Esophageal dilation
Allergy testing
Elimination diets based on allergy testing

Risk Factors

1Male gender
2Atopic conditions (asthma, eczema, allergies)
3Family history
4Food allergies
5Climate (northern regions)
6Seasonal variations

Diagnostic Methods

  • 1Upper endoscopy with biopsy
  • 2Eosinophil count (>15/hpf)
  • 3Endoscopic features (rings, furrows, exudates)
  • 4Allergy testing
  • 5Elimination diet trials

Prognosis

Chronic relapsing condition. Treatments control symptoms but don't cure. Food triggers may change over time. Risk of esophageal stricture if untreated. Long-term management required. Good prognosis with treatment.

Prevention

  • Identify and avoid trigger foods
  • Early diagnosis
  • Regular follow-up
  • Adherence to treatment
  • Allergy management

Research Status

Six-food elimination diet effective. Topical corticosteroids (swallowed fluticasone or budesonide) standard. Proton pump inhibitors for some. Dupilumab (anti-IL-4Rα) FDA approved. Dilatation for strictures. Food allergy testing guides elimination diets.

Affected Countries

United StatesUnited KingdomCanadaAustraliaGermanyFranceItalySpainJapanBrazilMexicoSwedenNetherlandsNorwayFinlandDenmark

Sources

  • https://www.mayoclinic.org/diseases-conditions/eosinophilic-esophagitis
  • https://www.ncbi.nlm.nih.gov/books
  • https://www.mayoclinic.org/diseases-conditions
  • https://www.crohnscolitisfoundation.org

Medical Disclaimer

This information is for educational purposes only. Always consult healthcare professionals for medical advice, diagnosis, and treatment.