DISEASE SCANNER

Global Incurable Diseases Tracker

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Gynecologic Condition

Endometrial Hyperplasia

MODERATE

Thickening of the uterine lining (endometrium) due to excessive proliferation of endometrial glands. Can be simple or complex, with or without atypia. Atypical hyperplasia is considered a precancerous condition.

Global Affected

2.0M

Countries

15

Symptoms

Abnormal uterine bleeding
Heavy menstrual bleeding
Bleeding between periods
Postmenopausal bleeding
Pelvic pain
Difficulty getting pregnant

Treatment Options

Progestin therapy
Levonorgestrel IUD
Oral progestins
Hysterectomy (atypical cases)
Weight management
Metformin (PCOS patients)
Close monitoring

Risk Factors

1Obesity
2PCOS
3Diabetes
4Tamoxifen use
5Estrogen-only hormone therapy
6Late menopause
7Nulliparity
8Age over 35

Diagnostic Methods

  • 1Endometrial biopsy
  • 2Transvaginal ultrasound
  • 3Hysteroscopy
  • 4Dilation and curettage (D&C)
  • 5MRI (for complex cases)

Prognosis

Simple hyperplasia without atypia has less than 5% progression risk to cancer. Complex atypical hyperplasia has 25-50% risk of concurrent endometrial cancer. Progestin therapy achieves regression in 70-90% of atypical cases. Hysterectomy provides definitive cure. Weight loss significantly reduces recurrence risk.

Prevention

  • Weight management
  • Regular exercise
  • Balanced hormone therapy
  • Managing PCOS and diabetes
  • Regular gynecologic exams

Research Status

Progestin therapy (oral or IUD) first-line for atypical hyperplasia. Hysterectomy for atypical hyperplasia in women not desiring fertility. Weight loss crucial for obese patients. Close surveillance with endometrial biopsies.

Affected Countries

United StatesUnited KingdomCanadaAustraliaGermanyFranceItalySpainJapanBrazilMexicoIndiaChinaNigeriaSouth Africa

Sources

  • https://www.acog.org
  • https://www.cancer.gov
  • https://www.mayoclinic.org

Medical Disclaimer

This information is for educational purposes only. Always consult healthcare professionals for medical advice, diagnosis, and treatment.