DISEASE SCANNER

Global Incurable Diseases Tracker

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Cancer

Endometrial Cancer (Uterine Cancer)

MODERATE

Cancer that begins in the lining of the uterus (endometrium). Most common gynecologic cancer in developed countries. Type I (endometrioid) associated with estrogen; Type II (serous) more aggressive.

Global Affected

400.0K

Countries

29

Symptoms

Abnormal vaginal bleeding
Bleeding after menopause
Pelvic pain
Pain during intercourse
Unusual vaginal discharge
Weight loss
Pain during urination

Treatment Options

Total hysterectomy
Bilateral salpingo-oophorectomy
Lymph node dissection
Radiation therapy
Chemotherapy
Hormone therapy
Immunotherapy
Targeted therapy
Fertility-sparing (selected cases)

Risk Factors

1Obesity
2Age (over 50)
3Estrogen-only HRT
4Tamoxifen use
5Nulliparity
6Late menopause
7Diabetes
8Lynch syndrome
9PCOS
10Prior pelvic radiation

Diagnostic Methods

  • 1Pelvic examination
  • 2Transvaginal ultrasound
  • 3Endometrial biopsy
  • 4D&C
  • 5Hysteroscopy
  • 6CT/MRI (staging)
  • 7PET scan
  • 8Genetic testing (Lynch)

Prognosis

Good overall; 81% 5-year survival. Early-stage disease highly curable. Type II and advanced stage have worse prognosis. Obesity epidemic contributing to rising incidence. Regular follow-up essential.

Prevention

  • Maintain healthy weight
  • Exercise regularly
  • Manage diabetes
  • Consider progestin with estrogen HRT
  • Lynch syndrome screening
  • Regular gynecologic exams

Research Status

Surgery (hysterectomy) curative for early-stage. Minimally invasive approaches standard. Sentinel lymph node mapping increasingly used. Immunotherapy (pembrolizumab/lenvatinib) for advanced. Molecular classification guiding treatment.

Affected Countries

United StatesUnited KingdomCanadaAustraliaGermanyFranceItalySpainJapanBrazilMexicoNigeriaSouth AfricaEgyptIndiaChinaRussiaTurkeyIranAustraliaNew ZealandSwedenNorwayFinlandDenmarkNetherlandsBelgiumSwitzerlandAustria

Sources

  • https://www.cancer.org/cancer/endometrial-cancer.html
  • https://www.foundationforwomenscancer.org/types-of-gynecologic-cancers/uterine-endometrial-cancer
  • https://www.mayoclinic.org/diseases-conditions/endometrial-cancer

Medical Disclaimer

This information is for educational purposes only. Always consult healthcare professionals for medical advice, diagnosis, and treatment.