DISEASE SCANNER

Global Incurable Diseases Tracker

Back to Globe
Genetic Disorder

Emery-Dreifuss Muscular Dystrophy

HIGH SEVERITY

A muscular dystrophy characterized by joint contractures (elbows, ankles, spine), slowly progressive muscle wasting and weakness, and cardiac conduction defects. X-linked (EDMD1/EMD), autosomal dominant (EDMD2/LMNA, EDMD3), and recessive forms.

Global Affected

80.0K

Countries

15

Symptoms

Joint contractures
Muscle weakness (humeroperoneal)
Cardiac conduction defects
Cardiomyopathy
Sudden cardiac death risk
Respiratory weakness (late)

Treatment Options

Genetic counseling
Supportive care
Symptom management
Enzyme replacement (if applicable)
Physical therapy
Regular monitoring
Multidisciplinary care

Risk Factors

1Family history
2Genetic mutations
3Consanguinity
4Advanced paternal age
5Ethnic predisposition

Diagnostic Methods

  • 1Genetic testing
  • 2Clinical evaluation
  • 3Family history assessment
  • 4Specialized laboratory tests
  • 5Imaging studies
  • 6Biopsy (if applicable)

Prognosis

Variable progression. Cardiac involvement universal, requires pacemaker. Contractures develop early. Ambulation usually preserved until late adulthood. Life expectancy reduced, mainly due to cardiac complications.

Prevention

  • Genetic counseling
  • Carrier screening
  • Prenatal diagnosis
  • Preimplantation genetic diagnosis
  • Family planning

Research Status

Cardiac monitoring and pacemaker/ICD placement essential. Supportive care. Heart transplant for severe cardiomyopathy. No disease-modifying therapy. Sudden death prevention through cardiac management is priority.

Sources

  • https://www.ncbi.nlm.nih.gov/books/NBK1116
  • https://medlineplus.gov/genetics
  • https://rarediseases.org

Medical Disclaimer

This information is for educational purposes only. Always consult healthcare professionals for medical advice, diagnosis, and treatment.