DISEASE SCANNER

Global Incurable Diseases Tracker

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Rare Disease

Ectopic Pregnancy

HIGH SEVERITY

A potentially life-threatening condition where a fertilized egg implants and grows outside the main cavity of the uterus, most commonly in a fallopian tube. The pregnancy cannot proceed normally and can cause the fallopian tube to rupture, leading to severe internal bleeding. Requires immediate medical intervention.

Global Affected

3.0M

Countries

122

Symptoms

Sharp abdominal or pelvic pain
Vaginal bleeding or spotting
Shoulder pain (referred pain from bleeding)
Weakness, dizziness, or fainting
Nausea with pain
Rectal pressure
Missed period
Positive pregnancy test
Signs of shock (if ruptured)

Treatment Options

Methotrexate (medical management)
Laparoscopic salpingostomy (tube-sparing)
Laparoscopic salpingectomy (tube removal)
Laparotomy (open surgery)
Expectant management (select cases)
Blood transfusion (if hemorrhage)
Close hCG monitoring
Follow-up care

Risk Factors

1Previous ectopic pregnancy
2Pelvic inflammatory disease (PID)
3Endometriosis
4Tubal surgery or ligation
5Infertility treatments (IVF)
6Smoking
7Age >35
8Previous pelvic or abdominal surgery
9Sexually transmitted infections
10Conception with IUD in place
11Use of assisted reproductive technology

Diagnostic Methods

  • 1Transvaginal ultrasound
  • 2Serial hCG blood tests
  • 3Progesterone levels
  • 4Culdocentesis (rarely used)
  • 5Laparoscopy (diagnostic and therapeutic)
  • 6CBC (to check for anemia/bleeding)

Prognosis

Life-threatening if rupture occurs without treatment. Mortality low (<0.5%) with modern care. Fertility after treatment: 60-70% chance of intrauterine pregnancy. 10-25% recurrence risk. Future fertility depends on tubal status and treatment type. Salpingostomy preserves fertility but has higher recurrence risk.

Prevention

  • Prompt treatment of sexually transmitted infections
  • Smoking cessation
  • Pelvic infection prevention
  • Early prenatal care
  • Risk factor screening
  • Transvaginal ultrasound for early pregnancy confirmation in high-risk women

Research Status

Methotrexate for unruptured, stable, small ectopic pregnancies with low hCG. Surgery (salpingectomy or salpingostomy) for ruptured, large, or unstable cases. Laparoscopic approach preferred. Expectant management for select cases with declining hCG. Early detection via transvaginal ultrasound and hCG monitoring crucial.

Sources

  • https://www.mayoclinic.org/diseases-conditions/ectopic-pregnancy
  • https://www.acog.org/womens-health/faqs/ectopic-pregnancy
  • https://www.hematology.org/education/patients
  • https://www.ncbi.nlm.nih.gov/books
  • https://rarediseases.org/rare-diseases

Medical Disclaimer

This information is for educational purposes only. Always consult healthcare professionals for medical advice, diagnosis, and treatment.