DISEASE SCANNER

Global Incurable Diseases Tracker

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Endocrine Disorder

Type 2 Diabetes (Adult-Onset Diabetes)

HIGH SEVERITY

A chronic metabolic disorder characterized by high blood sugar, insulin resistance, and relative lack of insulin. The most common form of diabetes, accounting for 90-95% of cases. Often preventable and sometimes reversible with lifestyle changes.

Global Affected

462.0M

Countries

138

Symptoms

Increased thirst
Frequent urination
Increased hunger
Unintended weight loss
Fatigue
Blurred vision
Slow-healing sores
Frequent infections
Numbness or tingling
Darkened skin (acanthosis nigricans)

Treatment Options

Hormone replacement
Hormone suppression
Medications
Surgery
Radiation therapy
Lifestyle modifications
Regular monitoring

Risk Factors

1Family history
2Autoimmune disease
3Age
4Obesity
5Genetic mutations
6Iodine deficiency/excess
7Medications
8Pituitary tumors

Diagnostic Methods

  • 1Hormone level testing
  • 2Imaging (CT, MRI, ultrasound)
  • 3Stimulation/suppression tests
  • 4Autoantibody testing
  • 5Genetic testing

Prognosis

Generally excellent with proper hormone replacement or suppression. Lifelong monitoring typically required. Complications preventable with good control.

Prevention

  • Screening for at-risk individuals
  • Iodine sufficiency
  • Avoidance of trigger medications
  • Genetic counseling
  • Lifestyle modifications

Research Status

Lifestyle modification (diet, exercise, weight loss) first-line. Metformin initial pharmacotherapy. SGLT2 inhibitors and GLP-1 receptor agonists showing cardiovascular and renal benefits. Insulin therapy when needed. Bariatric surgery can induce remission in eligible patients.

Sources

  • https://www.endocrine.org
  • https://www.ncbi.nlm.nih.gov/books/NBK278949
  • https://www.hematology.org/education/patients
  • https://www.ncbi.nlm.nih.gov/books
  • https://rarediseases.org/rare-diseases

Medical Disclaimer

This information is for educational purposes only. Always consult healthcare professionals for medical advice, diagnosis, and treatment.