DISEASE SCANNER

Global Incurable Diseases Tracker

Back to Globe
Endocrine Disorder

Cushing's Syndrome

HIGH SEVERITY

A disorder caused by prolonged exposure to high cortisol levels, either from exogenous steroids or endogenous overproduction (pituitary adenoma, adrenal tumor, or ectopic ACTH). Affects metabolism and multiple organ systems.

Global Affected

40.0K

Countries

15

Symptoms

Central obesity
Moon face
Buffalo hump
Purple striae
High blood pressure
Diabetes
Osteoporosis
Muscle weakness
Mood changes

Treatment Options

Hormone replacement
Hormone suppression
Medications
Surgery
Radiation therapy
Lifestyle modifications
Regular monitoring

Risk Factors

1Family history
2Autoimmune disease
3Age
4Obesity
5Genetic mutations
6Iodine deficiency/excess
7Medications
8Pituitary tumors

Diagnostic Methods

  • 1Hormone level testing
  • 2Imaging (CT, MRI, ultrasound)
  • 3Stimulation/suppression tests
  • 4Autoantibody testing
  • 5Genetic testing

Prognosis

Generally excellent with proper hormone replacement or suppression. Lifelong monitoring typically required. Complications preventable with good control.

Prevention

  • Screening for at-risk individuals
  • Iodine sufficiency
  • Avoidance of trigger medications
  • Genetic counseling
  • Lifestyle modifications

Research Status

Surgery for pituitary or adrenal tumors. Mifepristone for hyperglycemia. Pasireotide for Cushing's disease. Ketoconazole, metyrapone, mitotane for medical management. Bilateral adrenalectomy for refractory cases.

Affected Countries

AustraliaBrazilCanadaGermanyEESpainFranceUnited KingdomIndiaItalyJapanMexicoTaiwanUnited StatesVietnam

Sources

  • https://www.endocrine.org
  • https://www.ncbi.nlm.nih.gov/books/NBK278949
  • https://www.hematology.org/education/patients
  • https://www.ncbi.nlm.nih.gov/books
  • https://rarediseases.org/rare-diseases

Medical Disclaimer

This information is for educational purposes only. Always consult healthcare professionals for medical advice, diagnosis, and treatment.