DISEASE SCANNER

Global Incurable Diseases Tracker

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Autoimmune Disease

Crohn's Disease

MODERATE

A type of inflammatory bowel disease (IBD) causing chronic inflammation of the gastrointestinal tract from mouth to anus, most commonly affecting the ileum and colon. Transmural inflammation can cause strictures, fistulas, and abscesses.

Global Affected

3.2M

Countries

15

Symptoms

Diarrhea (may be bloody)
Abdominal pain and cramping
Fatigue
Weight loss and malnutrition
Fever
Perianal disease (fissures, fistulas)

Treatment Options

Corticosteroids
Immunosuppressants
Biologic agents
DMARDs
Plasmapheresis
IVIG
Physical therapy
Symptom management

Risk Factors

1Female gender
2Family history
3Genetic predisposition
4Environmental triggers
5Infections
6Hormonal factors
7Smoking

Diagnostic Methods

  • 1Autoantibody testing
  • 2Inflammatory markers
  • 3Imaging
  • 4Biopsy
  • 5Clinical criteria
  • 6Exclusion of other causes

Prognosis

Variable; many autoimmune diseases are chronic with relapsing-remitting courses. Early treatment and modern biologics have significantly improved outcomes.

Prevention

  • No specific prevention
  • Smoking cessation
  • Avoidance of triggers
  • Early diagnosis and treatment
  • Regular monitoring

Research Status

Anti-TNF agents (infliximab, adalimumab), IL-12/23 inhibitor (ustekinumab), and JAK inhibitors effective. Stem cell therapy trials ongoing. Surgery required in 70% of patients within 10 years.

Affected Countries

AustraliaCanadaGermanySpainFinlandFranceUnited KingdomItalyJapanLVNetherlandsNorwayRussiaSwedenUnited States

Sources

  • https://www.ncbi.nlm.nih.gov/books/NBK519046
  • https://www.ncbi.nlm.nih.gov/books
  • https://www.mayoclinic.org/diseases-conditions
  • https://rarediseases.org/rare-diseases

Medical Disclaimer

This information is for educational purposes only. Always consult healthcare professionals for medical advice, diagnosis, and treatment.