DISEASE SCANNER
Global Incurable Diseases Tracker
Congenital Dyserythropoietic Anemia (CDA)
Rare inherited blood disorder characterized by ineffective erythropoiesis, leading to anemia, iron overload, and characteristic bone marrow abnormalities. Three main types with type I and II being most common.
25.0K
15
Symptoms
Treatment Options
Risk Factors
Diagnostic Methods
- 1Complete blood count
- 2Peripheral blood smear
- 3Bone marrow examination
- 4Serum ferritin
- 5Genetic testing
- 6Electron microscopy of bone marrow
Prognosis
Variable depending on type and severity. Type I: moderate anemia, transfusions often not needed. Type II: more severe, may require regular transfusions. Iron overload is major complication requiring lifelong chelation. Splenectomy can reduce transfusion needs by 50%. Stem cell transplant curative but risky. Life expectancy reduced without proper iron management.
Prevention
- Genetic counseling
- Prenatal diagnosis
- Family screening
- Early iron monitoring
Research Status
Supportive care with transfusions as needed. Interferon alpha-2a for CDA type I. Splenectomy may reduce transfusion requirements. Iron chelation essential. Allogeneic stem cell transplant curative option.
Affected Countries
Sources
- https://www.ncbi.nlm.nih.gov/books/NBK194415
- https://www.hematology.org
- https://rarediseases.org
Medical Disclaimer
This information is for educational purposes only. Always consult healthcare professionals for medical advice, diagnosis, and treatment.