DISEASE SCANNER

Global Incurable Diseases Tracker

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Gastroenterologic Disease

Chronic Constipation

LOW SEVERITY

Infrequent bowel movements or difficulty passing stools that persists for several weeks or longer. Can significantly affect quality of life. Various types: normal transit, slow transit, and outlet dysfunction.

Global Affected

700.0M

Countries

19

Symptoms

Passing fewer than 3 stools/week
Lumpy or hard stools
Straining
Feeling of blockage
Incomplete evacuation
Needing manual assistance
Abdominal bloating

Treatment Options

Dietary fiber
Osmotic laxatives
Stimulant laxatives
Stool softeners
Lubiprostone
Linaclotide
Plecanatide
Prucalopride
Biofeedback therapy
Enemas (occasional use)

Risk Factors

1Female gender
2Age (older adults)
3Dehydration
4Low fiber diet
5Sedentary lifestyle
6Certain medications
7Pregnancy
8Hypothyroidism
9Diabetes
10Parkinson's disease

Diagnostic Methods

  • 1Rome IV criteria
  • 2Physical examination
  • 3Blood tests
  • 4Thyroid function tests
  • 5Colonoscopy (if red flags)
  • 6Anorectal manometry
  • 7Balloon expulsion test
  • 8Defecography

Prognosis

Chronic but manageable. Treatments effective for most. Lifestyle modifications important. Some require long-term laxative use. Rarely leads to serious complications (fecal impaction, megacolon).

Prevention

  • Adequate fluid intake
  • High fiber diet
  • Regular exercise
  • Don't ignore urge
  • Establish toilet routine
  • Limit constipating medications
  • Manage underlying conditions

Research Status

Osmotic and stimulant laxatives first-line. Lubiprostone, linaclotide, plecanatide, and prucalopride for CIC. Biofeedback effective for outlet dysfunction. Dietary fiber helpful for some. Research into microbiome and prokinetics ongoing.

Sources

  • https://www.mayoclinic.org/diseases-conditions/constipation
  • https://www.niddk.nih.gov/health-information/digestive-diseases/constipation
  • https://www.ncbi.nlm.nih.gov/books
  • https://www.mayoclinic.org/diseases-conditions
  • https://www.crohnscolitisfoundation.org

Medical Disclaimer

This information is for educational purposes only. Always consult healthcare professionals for medical advice, diagnosis, and treatment.