DISEASE SCANNER
Global Incurable Diseases Tracker
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Hepatologic Disease
Budd-Chiari Syndrome
HIGH SEVERITY
A rare condition caused by obstruction of hepatic venous outflow from thrombosis of hepatic veins or inferior vena cava. Acute form is life-threatening; chronic form causes cirrhosis. Associated with hypercoagulable states.
Global Affected
200.0K
Countries
18
Symptoms
Abdominal pain
Ascites
Hepatomegaly
Jaundice
Lower extremity edema
Fatigue
Nausea/vomiting
Hepatic encephalopathy
Treatment Options
Anticoagulation
Thrombolysis
Angioplasty/stenting
TIPS procedure
Liver transplantation
Diuretics
Treatment of underlying cause
Risk Factors
1Myeloproliferative neoplasms
2Factor V Leiden
3Prothrombin G20210A
4Antiphospholipid syndrome
5Oral contraceptives
6Pregnancy
7Paroxysmal nocturnal hemoglobinuria
Diagnostic Methods
- 1Doppler ultrasound
- 2CT/MR venography
- 3Liver biopsy
- 4Hypercoagulability workup
- 5JAK2 mutation testing
- 6Bone marrow biopsy
Prognosis
Variable; 5-year survival 50-90% depending on severity and treatment. Transplant-free survival improved with TIPS.
Prevention
- Anticoagulation (if prothrombotic)
- Management of underlying conditions
- Avoidance of oral contraceptives (high-risk)
- Early diagnosis
Research Status
Anticoagulation and Thrombolysis are primary treatments. Research focuses on improved therapies and outcomes.
Affected Countries
Sources
- https://www.niddk.nih.gov/health-information/liver-disease/budd-chiari-syndrome
- https://www.liverfoundation.org/for-patients/about-the-liver/diseases-of-the-liver
- https://www.ncbi.nlm.nih.gov/books/NBK470433
Medical Disclaimer
This information is for educational purposes only. Always consult healthcare professionals for medical advice, diagnosis, and treatment.