DISEASE SCANNER
Global Incurable Diseases Tracker
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Cardiac Disease
Brugada Syndrome
HIGH SEVERITY
An inherited channelopathy characterized by specific ECG pattern (coved ST elevation) in V1-V3 and increased risk of ventricular fibrillation and sudden cardiac death. Most common in Southeast Asian males. Often presents during sleep or fever.
Global Affected
1.0M
Countries
21
Symptoms
Syncope
Sudden cardiac death
Palpitations
Nocturnal agonal respiration
Often asymptomatic
Cardiac arrest
Seizures
Treatment Options
ICD (only proven therapy)
Quinidine (adjunctive)
Isoproterenol (acute electrical storms)
Ablation (epicardial substrate)
Avoidance of fever
Avoidance of specific drugs
Family screening
Risk Factors
1SCN5A gene mutations
2Male gender
3Asian ancestry
4Fever
5Family history
6Syncope
7Spontaneous type 1 ECG
Diagnostic Methods
- 112-lead ECG
- 2Flecainide/procainamide challenge
- 3Genetic testing
- 4Electrophysiology study
- 5Signal-averaged ECG
- 6Family screening
Prognosis
Variable; 0.5-1.5% annual event rate in symptomatic patients. ICD prevents sudden death. Asymptomatic patients have better prognosis.
Prevention
- Genetic counseling
- Family screening
- ICD implantation (high-risk)
- Avoidance of fever
- Avoidance of contraindicated drugs
Research Status
ICD (only proven therapy) and Quinidine (adjunctive) are primary treatments. Research focuses on improved therapies and outcomes.
Affected Countries
Sources
- https://www.heart.org/en/health-topics/arrhythmia
- https://www.ncbi.nlm.nih.gov/books/NBK1512
- https://www.hematology.org/education/patients
- https://www.ncbi.nlm.nih.gov/books
- https://rarediseases.org/rare-diseases
Medical Disclaimer
This information is for educational purposes only. Always consult healthcare professionals for medical advice, diagnosis, and treatment.