DISEASE SCANNER

Global Incurable Diseases Tracker

Back to Globe
Psychiatric Condition

Borderline Personality Disorder (BPD)

HIGH SEVERITY

A complex personality disorder characterized by pervasive instability in mood, interpersonal relationships, self-image, and behavior. Affects 1-2% of the general population and up to 20% of psychiatric inpatients. Associated with high rates of self-harm, suicide attempts, and significant functional impairment.

Global Affected

78.0M

Countries

20

Symptoms

Intense fear of abandonment
Unstable relationships (idealization/devaluation)
Identity disturbance
Impulsivity in self-damaging areas
Recurrent suicidal behavior or self-harm
Chronic feelings of emptiness
Inappropriate intense anger
Paranoid ideation under stress
Mood instability

Treatment Options

Dialectical behavior therapy (DBT)
Schema therapy
Mentalization-based therapy
Transference-focused psychotherapy
SSRIs for mood symptoms
Mood stabilizers for impulsivity
Atypical antipsychotics (low dose)
Stepped care models

Risk Factors

1Childhood trauma or abuse
2Neglect in early attachment
3Family history of BPD
4Genetic factors
5Invalidating environment during childhood
6Early separation or loss
7Parental substance abuse or mental illness
8Female gender (3:1 ratio)

Diagnostic Methods

  • 1Structured Clinical Interview for DSM-5
  • 2McLean Screening Instrument for BPD
  • 3Borderline Evaluation of Severity over Time (BEST)
  • 4Zanarini Rating Scale for BPD
  • 5Comprehensive clinical assessment
  • 6Assessment of self-harm and suicide risk
  • 7Evaluation of trauma history

Prognosis

Better than previously thought - 50% achieve remission within 10 years with treatment. Suicide rate 8-10% over lifetime. 75% attempt suicide at least once. With DBT, suicide attempts reduced by 50%, hospitalizations by 70%. Relapse possible under stress. Quality of life improves significantly with treatment. Functional recovery lags behind symptom remission. Comorbid depression, substance abuse, and eating disorders common. Good social support predicts better outcomes. Ten-year remission rate 85% with sustained treatment.

Prevention

  • Early intervention for adolescents with emerging symptoms
  • Treatment of childhood trauma
  • Family psychoeducation
  • Skills training in emotion regulation
  • Building supportive relationships
  • Distress tolerance skills
  • Crisis planning and management
  • Reducing access to means of self-harm

Research Status

Dialectical behavior therapy (DBT) is gold-standard treatment with strong evidence. Schema therapy and mentalization-based therapy also effective. Research on emotional dysregulation, attachment trauma, and neurobiological factors. Good prognosis with appropriate treatment - 50% remit within 10 years.

Sources

  • https://www.mayoclinic.org/diseases-conditions/borderline-personality-disorder
  • https://www.who.int/news-room/fact-sheets/detail/personality-disorders
  • https://www.hematology.org/education/patients
  • https://www.ncbi.nlm.nih.gov/books
  • https://rarediseases.org/rare-diseases

Medical Disclaimer

This information is for educational purposes only. Always consult healthcare professionals for medical advice, diagnosis, and treatment.