DISEASE SCANNER
Global Incurable Diseases Tracker
Aplastic Anemia
A rare serious condition where the bone marrow fails to produce sufficient blood cells (pancytopenia). Can be idiopathic, autoimmune, or caused by toxins, radiation, or certain medications. Median age of onset 25 years.
200.0K
15
Symptoms
Treatment Options
Risk Factors
Diagnostic Methods
- 1Complete blood count
- 2Peripheral smear
- 3Bone marrow biopsy
- 4Coagulation studies
- 5Hemoglobin electrophoresis
- 6Flow cytometry
- 7Genetic testing
Prognosis
Severe untreated: 3-6 month survival. With immunosuppression: 70-80% response rate, 5-year survival 70-80%. Transplant: 80-90% long-term survival with matched sibling donor. Clonal evolution to MDS/leukemia risk 10-15%.
Prevention
- Genetic counseling
- Nutritional adequacy
- Avoidance of triggers
- Vaccinations
- Regular monitoring
- Family screening
Research Status
Immunosuppressive therapy (ATG, cyclosporine) for non-severe cases. Young patients: allogeneic stem cell transplant curative. Eltrombopag approved for refractory cases. Supportive care with transfusions.
Affected Countries
Sources
- https://www.hematology.org
- https://medlineplus.gov/blooddiseases.html
- https://www.hematology.org/education/patients
- https://www.ncbi.nlm.nih.gov/books
- https://rarediseases.org/rare-diseases
Medical Disclaimer
This information is for educational purposes only. Always consult healthcare professionals for medical advice, diagnosis, and treatment.