DISEASE SCANNER

Global Incurable Diseases Tracker

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Psychiatric Condition

Anorexia Nervosa

HIGH SEVERITY

A serious eating disorder characterized by restriction of energy intake leading to significantly low body weight, intense fear of gaining weight, and disturbed body image. Has the highest mortality rate of any psychiatric disorder. Affects approximately 0.5-1% of women and 0.1-0.3% of men, typically beginning in adolescence.

Global Affected

32.0M

Countries

18

Symptoms

Significantly low body weight
Intense fear of weight gain
Disturbed body image
Food restriction and dieting behaviors
Excessive exercise
Amenorrhea (loss of menstrual periods)
Preoccupation with food and weight
Social withdrawal
Cold intolerance and fatigue

Treatment Options

Family-based treatment (adolescents)
CBT-E (cognitive behavioral therapy enhanced)
Nutritional rehabilitation
Medical monitoring and stabilization
Olanzapine for weight restoration
Fluoxetine (after weight restored)
Inpatient or residential treatment
Support groups and self-help

Risk Factors

1Female gender (10:1 ratio)
2Perfectionism and high achievement orientation
3Family history of eating disorders
4History of dieting
5Athletic or artistic pressure for thinness
6Peer and media influence
7Trauma or abuse history
8Comorbid anxiety or OCD

Diagnostic Methods

  • 1DSM-5 criteria assessment
  • 2Eating Disorder Examination
  • 3Medical evaluation (vitals, ECG, labs)
  • 4BMI calculation
  • 5Bone density scan (DEXA)
  • 6Assessment of medical complications
  • 7Psychiatric comorbidity screening

Prognosis

Standardized mortality ratio 5-10x general population; 5-10% die over 10 years. 50% fully recover, 30% partially recover, 20% have chronic course. Early intervention improves outcomes significantly. Relapse common during stress. Osteoporosis and cardiac complications may be permanent. With treatment, weight restoration achieved in 60-80%. Recovery often takes 5-7 years. Mortality from suicide, cardiac arrest, or medical complications. Treatment during first 3 years of illness has best outcomes.

Prevention

  • Body image programs in schools
  • Media literacy education
  • Early identification of risk factors
  • Family-based prevention programs
  • Reducing weight-related teasing
  • Promoting intuitive eating
  • Mental health screening in schools

Research Status

Family-based treatment (FBT) is first-line for adolescents. CBT-E (enhanced) effective for adults. Nutritional rehabilitation essential. Research on set-point theory, reward processing abnormalities, and gut-brain axis. Olanzapine may aid weight restoration. Early intervention critical.

Sources

  • https://www.mayoclinic.org/diseases-conditions/anorexia-nervosa
  • https://www.who.int/news-room/fact-sheets/detail/eating-disorders
  • https://www.hematology.org/education/patients
  • https://www.ncbi.nlm.nih.gov/books
  • https://rarediseases.org/rare-diseases

Medical Disclaimer

This information is for educational purposes only. Always consult healthcare professionals for medical advice, diagnosis, and treatment.