DISEASE SCANNER
Global Incurable Diseases Tracker
Alzheimer's Disease
A progressive neurodegenerative brain disorder and the most common cause of dementia. Characterized by amyloid plaques and neurofibrillary tangles. Risk increases significantly with age, though not a normal part of aging.
55.0M
15
Symptoms
Treatment Options
Risk Factors
Diagnostic Methods
- 1Neurological examination
- 2MRI/CT imaging
- 3EEG
- 4EMG/NCV
- 5Lumbar puncture
- 6Genetic testing
- 7Neuropsychological testing
Prognosis
Early-stage patients maintain independence for 2-4 years. Mild-to-moderate stage lasts 2-10 years with gradual cognitive decline. Severe stage typically 1-3 years with complete dependency. Cholinesterase inhibitors and memantine provide modest 6-12 month stabilization. Early diagnosis and intervention can delay nursing home placement by 1-2 years. Average survival from diagnosis is 4-8 years (range 3-20 years). Cardiovascular risk management slows progression.
Prevention
- Head protection
- Cardiovascular health
- Cognitive stimulation
- Physical exercise
- Healthy diet
- Avoidance of toxins
- Regular monitoring
Research Status
Anti-amyloid monoclonal antibodies FDA-approved: Lecanemab (Leqembi) and Donanemab show promise in slowing early-stage progression. Aduhelm (aducanumab) discontinued. Cholinesterase inhibitors and memantine for symptom management.
Affected Countries
Sources
- https://www.ncbi.nlm.nih.gov/books/NBK539800
- https://www.ncbi.nlm.nih.gov/books
- https://www.mayoclinic.org/diseases-conditions
- https://rarediseases.org/rare-diseases
Medical Disclaimer
This information is for educational purposes only. Always consult healthcare professionals for medical advice, diagnosis, and treatment.