DISEASE SCANNER

Global Incurable Diseases Tracker

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Endocrine Disorder

Addison's Disease (Primary Adrenal Insufficiency)

HIGH SEVERITY

A rare endocrine disorder where the adrenal glands do not produce sufficient cortisol and aldosterone. Often caused by autoimmune destruction of the adrenal cortex. Can be life-threatening during adrenal crisis.

Global Affected

140.0K

Countries

15

Symptoms

Fatigue
Muscle weakness
Weight loss
Low blood pressure
Salt craving
Hyperpigmentation
Nausea
Abdominal pain

Treatment Options

Hormone replacement
Hormone suppression
Medications
Surgery
Radiation therapy
Lifestyle modifications
Regular monitoring

Risk Factors

1Family history
2Autoimmune disease
3Age
4Obesity
5Genetic mutations
6Iodine deficiency/excess
7Medications
8Pituitary tumors

Diagnostic Methods

  • 1Hormone level testing
  • 2Imaging (CT, MRI, ultrasound)
  • 3Stimulation/suppression tests
  • 4Autoantibody testing
  • 5Genetic testing

Prognosis

Generally excellent with proper hormone replacement or suppression. Lifelong monitoring typically required. Complications preventable with good control.

Prevention

  • Screening for at-risk individuals
  • Iodine sufficiency
  • Avoidance of trigger medications
  • Genetic counseling
  • Lifestyle modifications

Research Status

Hormone replacement therapy (hydrocortisone, fludrocortisone) standard. Research on adrenal stem cell regeneration. Gene therapy trials for inherited forms. Better diagnostic assays for adrenal crisis prediction.

Affected Countries

AustraliaBrazilCanadaSwitzerlandGermanySpainFranceUnited KingdomHungaryIndiaItalyJapanMexicoNorwayUnited States

Sources

  • https://www.endocrine.org
  • https://www.ncbi.nlm.nih.gov/books/NBK278949
  • https://www.hematology.org/education/patients
  • https://www.ncbi.nlm.nih.gov/books
  • https://rarediseases.org/rare-diseases

Medical Disclaimer

This information is for educational purposes only. Always consult healthcare professionals for medical advice, diagnosis, and treatment.