DISEASE SCANNER

Global Incurable Diseases Tracker

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Dermatologic Condition

Severe Acne Vulgaris

MODERATE

A chronic inflammatory skin condition of the pilosebaceous unit characterized by comedones, papules, pustules, nodules, and cysts. Affects 85% of adolescents but can persist into adulthood. Severe forms include nodulocystic acne and acne conglobata with risk of permanent scarring.

Global Affected

650.0M

Countries

111

Symptoms

Comedones (blackheads/whiteheads)
Papules
Pustules
Nodules
Cysts
Oily skin
Scarring
Post-inflammatory hyperpigmentation
Pain/tenderness
Psychological distress

Treatment Options

Topical retinoids
Topical benzoyl peroxide
Topical antibiotics
Oral antibiotics
Hormonal therapy
Isotretinoin
Corticosteroid injections
Chemical peels
Laser/light therapy
Extraction procedures

Risk Factors

1Age (adolescence)
2Hormonal changes
3Family history
4High glycemic load diet
5Dairy consumption
6Stress
7Certain medications
8Cosmetics
9Mechanical irritation
10Occupational exposure to oils

Diagnostic Methods

  • 1Clinical diagnosis
  • 2Physical examination
  • 3Hormonal testing (if indicated)
  • 4Assessment for scarring
  • 5Psychological assessment

Prognosis

Usually improves with age but can persist into 30s-40s. With treatment, significant improvement expected. Risk of permanent scarring with severe untreated disease. Psychological impact can be significant.

Prevention

  • Gentle cleansing
  • Non-comedogenic products
  • Avoid picking/squeezing
  • Sun protection
  • Healthy diet
  • Stress management
  • Early treatment

Research Status

Isotretinoin remains gold standard for severe acne. Hormonal therapies (spironolactone, combined oral contraceptives) for females. Topical retinoids, benzoyl peroxide, antibiotics. Acne vaccines in early development. Microbiome modulation approaches.

Sources

  • https://www.cdc.gov/
  • https://www.hematology.org/education/patients
  • https://www.ncbi.nlm.nih.gov/books
  • https://rarediseases.org/rare-diseases

Medical Disclaimer

This information is for educational purposes only. Always consult healthcare professionals for medical advice, diagnosis, and treatment.